SEE WHO MIGHT BENEFIT FROM GEMTESA

Meet Laura,* a patient who experiences urgency episodes

Age 53
Teacher
Not currently taking OAB medication

My anxiety about finding a bathroom quickly is causing me to cancel plans and isolate myself.

*Not an actual patient

OAB Presentation and Impact

Persistent urgency episodes (3+ months) causing significant disruption in daily activities (work and personal)
Increased frequency and average of 3 daily urge urinary incontinence episodes have caused patient to limit water intake
Concerned about taking medications that impact existing hypertension
Increased anxiety due to fears about locating bathrooms in public settings

OAB Treatment Profile

Not previously treated with pharmacologic therapy
Currently using adult absorbent briefs

Comorbidities

Hypertension

Additional Medications

Metoprolol (metabolized by CYP2D6)^1,2

Meet Allison,* a patient who experiences urge urinary incontinence (UUI)

Age 67
Social Worker
Previously treated with mirabegron

I'm constantly carrying pads and a change of clothes in case I can't make it in time.

*Not an actual patient

OAB Presentation and Impact

Suffering from urgency episodes for more than 1 year since stopping treatment
Increased depression due to coping with approximately 3 urge urinary incontinence episodes daily
Experiences frequent UTIs in addition to her OAB symptoms
Expresses interest in improving UUI symptoms

OAB Treatment Profile

Previous medication: mirabegron (50 mg, once daily)
- Side effects: increased blood pressure, headache, UTIs, and nasopharyngitis³

Comorbidities

Depression
Type 2 diabetes
Hypertension
Dyslipidemia

Additional Medications

Fluoxetine
(metabolized by CYP2D6)^1,2,4
Metformin
Metoprolol
(metabolized by CYP2D6)^1,2
Rosuvastatin

CYP2D6=cytochrome P450 2D6; UTI=urinary tract infection.

Ready to see how GEMTESA may be able to help patients like Laura and Allison?

Pivotal efficacy data

Want to see results from the 52-week extension study?

Extension study data

INDICATIONS AND USAGE

GEMTESA^® is a beta-3 adrenergic agonist indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

GEMTESA is contraindicated in patients with known hypersensitivity to vibegron or any components of the product.

WARNINGS AND PRECAUTIONS

Urinary Retention

Urinary retention has been reported in patients taking GEMTESA. The risk of urinary retention may be increased in patients with bladder outlet obstruction and also in patients taking muscarinic antagonist medications for the treatment of OAB. Monitor patients for signs and symptoms of urinary retention, particularly in patients with bladder outlet obstruction and patients taking muscarinic antagonist medications for the treatment of OAB. Discontinue GEMTESA in patients who develop urinary retention.

ADVERSE REACTIONS

Most common adverse reactions (≥2%) reported with GEMTESA were headache, urinary tract infection, nasopharyngitis, diarrhea, nausea, and upper respiratory tract infection.

Please see full Prescribing Information.

References: 1. Hansten PD, Horn JR. The Top 100 Drug Interactions; A Guide to Patient Management. 2019 ed. Freeland, WA: H&H Publications, LLP; 2019. 2. Kobriger A. Drug Use in Long-Term Care (Effects on Nutrition & Health Status). OnCourse Learning; 2011:i-170. 3. Myrbetriq® (mirabegron extended release tablets) [prescribing information]. Northbrook, IL: Astellas Pharma US, Inc; 2018. 4. Meeks TW, Culberson JW, Horton MS. Medications in long-term care: when less is more. Clin Geriatr Med. 2011;27(2):171-191. doi:10.1016/j.cger.2011.01.003