SEE WHO MIGHT BENEFIT FROM GEMTESA
Meet Laura,* a patient who experiences urgency episodes
Age 53
Teacher
Not currently taking OAB medication

OAB Presentation and Impact
- Persistent urgency episodes (3+ months) causing significant disruption in daily activities (work and personal)
- Increased frequency and average of 3 daily urge urinary incontinence episodes have caused patient to limit water intake
- Concerned about taking medications that impact existing hypertension
- Increased anxiety due to fears about locating bathrooms in public settings
OAB Treatment Profile
- Not previously treated with pharmacologic therapy
- Currently using adult absorbent briefs
Comorbidities
- Hypertension
Additional Medications
- Metoprolol (metabolized by CYP2D6)1,2
Meet Allison,* a patient who experiences urge urinary incontinence (UUI)
Age 67
Social Worker
Previously treated with mirabegron

OAB Presentation and Impact
- Suffering from urgency episodes for more than 1 year since stopping treatment
- Increased depression due to coping with approximately 3 urge urinary incontinence episodes daily
- Experiences frequent UTIs in addition to her OAB symptoms
- Expresses interest in improving UUI symptoms
OAB Treatment Profile
- Previous medication: mirabegron (50 mg, once daily)
- Side effects: increased blood pressure, headache, UTIs, and nasopharyngitis3
Comorbidities
- Depression
- Type 2 diabetes
- Hypertension
- Dyslipidemia
Additional Medications
- Fluoxetine
(metabolized by CYP2D6)1,2,4 - Metformin
- Metoprolol
(metabolized by CYP2D6)1,2 - Rosuvastatin
CYP2D6=cytochrome P450 2D6; UTI=urinary tract infection.
References: 1. Hansten PD, Horn JR. The Top 100 Drug Interactions; A Guide to Patient Management. 2019 ed. Freeland, WA: H&H Publications, LLP; 2019. 2. Kobriger A. Drug Use in Long-Term Care (Effects on Nutrition & Health Status). OnCourse Learning; 2011:i-170. 3. Myrbetriq® (mirabegron extended release tablets) [prescribing information]. Northbrook, IL: Astellas Pharma US, Inc; 2018. 4. Meeks TW, Culberson JW, Horton MS. Medications in long-term care: when less is more. Clin Geriatr Med. 2011;27(2):171-191. doi:10.1016/j.cger.2011.01.003